Will Garou fight Saitama?
yes,
you will see garou fight saitama two times in season 2. first time you will see fight between them is when garou is hunting A class heroes.
Can Saitama beat Garou with one punch?
He has tremendous capability to defeat any opponent with a single punch. He is expert in slaying the monsters also. However, Garou will be a big trouble for Saitama.
He won't be able to defeat Garou with a single punch.
Is Garou the same as Saitama?
In some ways,
Garou can be considered a foil to Saitama. Both of them have their own strong sense of honor and justice, albeit manifested in different ways. While Saitama wanted to be like a hero from his childhood who fought villains, Garou wants to be a monster who defeats heroes.